12th International Biometals Symposium (BioMetals 2020)

Mon. 06

Tue. 07

Wed. 08

Thu. 09

Fri. 10

Sat. 11

Sun. 12

Mon. 13

Tue. 14

Wed. 15

Thu. 16

Fri. 17

Sat. 18

15:00

16:00

17:00

18:00

19:00

Welcome and Introduction

15:00 - 15:10 (10min)

Welcome and Introduction

Chairman and IBS

Plenary Speech

15:10 - 16:00 (50min)

Plenary Speech

Main room

Hans Vogel

› Metal Sequestration by Calprotectin and Consequences on Microbial Physiology - Elizabeth Nolan, Massachusetts Institute of Technology 15:10-16:00 (50min)

BioMetals

16:00 - 16:50 (50min)

BioMetals

Main room

David Giedroc

› How cells help proteins to acquire the correct metals: Free energies of metalation - 16:02-16:32 (30min)

› Specificity factors that govern zinc-dependent assembly of CD4 coreceptor and Lck tyrosine kinase - 16:34-16:50 (16min)

Metals and host-pathogen interactions
Metalloproteins and biogenesis

16:50 - 17:20 (30min)

Metals and host-pathogen interactions

Main room

Flash - Simon Andrews

› The events that may contribute to subgingival dysbiosis: a focus on the interplay between iron, sulfide and oxygen - 16:50-16:54 (04min)

› Identification and characterization of iron transporters in Enterococcus faecalis - 16:54-16:58 (04min)

› Effect of iron on the development of oral biofilm. - 16:58-17:02 (04min)

› The influence of iron regime on the human gut microflora – an in vitro batch culture approach - 17:02-17:06 (04min)

› The role of the three lipocalins of egg-white in inhibition of Salmonella Enteritidis under iron restriction - 17:06-17:10 (04min)

16:50 - 17:20 (30min)

Metalloproteins and biogenesis

Auxiliary Room

Flash - Stefano Ciurli

› A luminescent peptide probe for extracellular Cu(II) detection - 16:50-16:54 (04min)

› OXIDATIVE STRESS RESPONSE ENZYMES: UNRAVELLING CATALYTIC DETERMINANTS OF SUPEROXIDE REDUCTASES THROUGH NATURAL AND SITE DIRECTED MUTANTS - 16:54-16:58 (04min)

› Copper (I) oxidation by a CueO-like oxidase from T. thermophilus studied by direct electrochemistry - 16:58-17:02 (04min)

› Biogenesis of Iron-Sulphur cluster binding proteins in human cytosol: An insight into the molecular mechanism of cluster delivery from GLRX3 to NUBP1 - 17:02-17:06 (04min)

› Biochemical and structural characterization of a new Flavorubredoxin from Photobacterium swingsii - 17:06-17:10 (04min)

Discussion Rooms

17:20 - 17:40 (20min)

Discussion Rooms

Metals and host-pathogen interactions

17:40 - 19:35 (1h55)

Metals and host-pathogen interactions

Main room

John Helmann

› Sensing the environment and the host: Iron transport and signalling in Pseudomonas - 17:40-18:10 (30min)

› Necrotrophic phytopathogens are protected from reactive oxygen species by a secreted metal-binding protein - 18:12-18:28 (16min)

› Effect of Iron on the Composition and Activity of the Gut Microbiota using in vitro Models - 18:29-18:45 (16min)

› Haem biosynthesis in Campylobacter jejuni - 18:46-19:02 (16min)

› Metallobiology at the host-pathogen interface: the case of tuberculosis - Olivier Neyrolles (invited) 19:03-19:33 (30min)

Discussion Rooms

19:35 - 19:45 (10min)

Discussion Rooms

Metal trafficking in micro-organisms

15:00 - 16:40 (1h40)

Metal trafficking in micro-organisms

Main room

Nigel Robinson

› Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli - 15:00-15:30 (30min)

› The three pillars of bacterial zinc homeostasis - 15:32-16:02 (30min)

› The Bacillus anthracis virulence-determinant ABC transporter MntBC-A: transport specificity and trans-membrane metal recognition - 16:04-16:20 (16min)

› Characterization of the Vibrio cholerae Feo Iron Transport System - 16:21-16:37 (16min)

Metal trafficking in micro-organisms
Metals in health and diseases

16:40 - 17:10 (30min)

Metal trafficking in micro-organisms

Main room

Flash - Dietrich Nies

› Investigating components of a Campylobacter jejuni gene cluster upregulated for iron scavenging during human infection - 16:40-16:44 (04min)

› The importance of conserved residues and the C-terminal sub-domain in FeoB-mediated iron uptake - 16:44-16:48 (04min)

› The Cup determinant is crucial for the resistance to copper in Cupriavidus metallidurans - 16:48-16:52 (04min)

› Siroheme biosynthesis in Staphylococcus aureus: insights of the pathway evolution in bacteria - 16:52-16:56 (04min)

16:40 - 17:10 (30min)

Metals in health and diseases

Auxiliary Room

Flash - Isabelle Michaud-Soret

› Empirical evidence supports an aetiological role for changes in biometal pathways in Parkinson's disease - 16:40-16:44 (04min)

› Long-lived kinetic intermediates explain Cu(II) exchange processes in ATCUN peptides - 16:44-16:48 (04min)

› B. cenocepacia increased antimicrobial resistance in the Cystic Fibrosis lung is associated with low pH and elevated levels of zinc and iron - 16:48-16:52 (04min)

› Design and study of anti-oxidant inorganic complexes mimicking the superoxide dismutase (SOD) - 16:52-16:56 (04min)

› Discovery through combinatorial chemistry of a peptidyl metal complex mimicking the antioxidant enzyme Catalase: characterization and in vitro/in vivo activity - Koudedja Couliably, Laboratoire des biomolécules 16:56-17:00 (04min)

Discussion Rooms

17:10 - 17:30 (20min)

Discussion Rooms

Metal trafficking in micro-organisms

17:30 - 18:00 (30min)

Metal trafficking in micro-organisms

Main room

Dietrich Nies

› How bacteria cope with silver ions - 17:30-18:00 (30min)

Siderophores, metallophores and chelators

18:00 - 19:25 (1h25)

Siderophores, metallophores and chelators

Main room

Debbie Crans

› The ancient roots of nicotianamine:diversity, role, regulation and evolution of nicotanamine-like metallophores - 18:02-18:32 (30min)

› Simple rules govern the diversity of bacterial nicotianamine-like metallophores - 18:34-18:50 (16min)

› Phenotypic adaptation of Pseudomonas aeruginosa in the presence of exosiderophores. - Quentin Perraud 18:51-19:07 (16min)

› Iron acquisition by Streptococcus pneumoniae: PiuA specifically recognizes tetradentate catechol FeIII complexes - 19:08-19:24 (16min)

Discussion Rooms

19:25 - 19:45 (20min)

Discussion Rooms

Siderophores, metallophores and chelators
Metals and environment

15:00 - 15:30 (30min)

Siderophores, metallophores and chelators

Auxiliary Room

Flash - Pascal Arnoux

› Azido-Desferrioxamine Siderophores as Functional Click- Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent - 15:00-15:04 (04min)

› Elucidating the mechanism for the biosynthesis of N-acetyl desferrioxamine siderophores - 15:04-15:08 (04min)

› A Novel Total Synthetic Approach to Desferrioxamine B Analogues - 15:08-15:12 (04min)

› IRON (III) AND GALLIUM (III) COMPLEXES OF FERRIOXAMINE E BIOMIMETIC ANALOGS - COORDINATION SPECIFICITY AND POSSIBLE APPLICATIONS - 15:12-15:16 (04min)

15:00 - 15:30 (30min)

Metals and environment

Main room

Flash - Katharina Frömm

› Deinococcus radiodurans' protection mechanisms against oxidative stress triggers the delocalization of intracellular metals - 15:00-15:04 (04min)

› Discovery and characterization of UipA, a uranium-binding protein involved in bacterial uranium tolerance - 15:04-15:08 (04min)

› In vitro biological water-gas shift reaction: characterization and grafting of recombinant Rhodospirillum rubrum CO-dehydrogenase - 15:08-15:12 (04min)

› Molecular mechanisms of Resistance to Radiation - 15:12-15:16 (04min)

› Dissecting the mechanism of cadmium toxicity in Deinococcus radiodurans R1 - 15:16-15:20 (04min)

Metals and environment

15:30 - 16:55 (1h25)

Metals and environment

Main room

Richard Ortega

› The fate of uranium in plants – Physiological and cellular effects - 15:32-16:02 (30min)

› Elucidating the mechanism of uranium uptake and processing in tobacco BY-2 cells - 16:04-16:20 (16min)

› A highly sensitive magnetic whole-cell biosensor for arsenic detection - 16:21-16:37 (16min)

› In vivo speciation and uptake mechanisms of Uranium in Paracentrotus lividus sea urchin and Laminaria digitata seaweed - 16:38-16:54 (16min)

Group picture

16:55 - 17:05 (10min)

Group picture

on screens

Discussion Rooms

17:05 - 17:20 (15min)

Discussion Rooms

Metal homeostasis and regulation

17:20 - 19:30 (2h10)

Metal homeostasis and regulation

Main room

Claudia Blindauer

› Manganese homeostasis in Bacillus subtilis - 17:20-17:50 (30min)

› Metalloregulation of cyanobacterial physiology operated by FUR (ferric uptake regulator) proteins - 17:52-18:22 (30min)

› Characterization of the stress-induced molecular signal that activates IrrE, a metalloprotease essential for extreme radiation resistance in Deinococcus bacteria. - 18:24-18:40 (16min)

› Zinc and iron homeostasis adjust a core metalloproteome and is reflected by the cellular metal composition, the metallome. - Martin Herzberg 18:41-18:57 (16min)

› A single zinc sensor mediates the response of an oligotrophic marine cyanobacterium to zinc excess and starvation - Claudia Blindauer (invited) 18:58-19:28 (30min)

Discussion Rooms

19:30 - 19:55 (25min)

Discussion Rooms

Metal homeostasis and regulation
Metals and host-pathogen interactions

15:00 - 15:45 (45min)

Metal homeostasis and regulation

Main room

Flash + oral - John Helmann

› Copper stress induces protein aggregation and triggers Hsp33 holdase function through a non-redox mechanism. - 15:00-15:04 (04min)

› Structural properties of the transcriptional regulator FurC (PerR) from Anabaena sp. PCC7120 and identification of a putative FurC-box - 15:04-15:08 (04min)

› Structural characterization of Deinococcus radiodurans Dps2 with manganese: Expression, purification and crystallization - 15:08-15:12 (04min)

› Interaction of Ferric Uptake Regulator FurA from Anabaena sp. PCC7120 with 2-oxoglutarate: a possible link between iron homeostasis and nitrogen metabolism - 15:12-15:16 (04min)

› Characterization of the stress-induced molecular signal that activates IrrE, a metalloprotease essential for extreme radiation resistance in Deinococcus bacteria. - Romaric Magerand, CEA-DRF-BIAM-MEM 15:16-15:20 (04min)

› Structural and Functional Characterization of Heme-Regulated Proteins in Iron Metabolism - 15:30-15:46 (16min)

15:00 - 15:30 (30min)

Metals and host-pathogen interactions

Auxiliary Room

Flash - Alain Stintzi

› Overcoming metal intoxication – Elucidating the zinc resistance pathways of Acinetobacter baumannii - 15:00-15:04 (04min)

› Biochemical and structural characterisation of the Haemophilus influenzae PsaA ortholog, HIPsaA - 15:04-15:08 (04min)

› Metal Sequestration and Antimicrobial Activity of Human Calprotectin are pH-Dependent - 15:08-15:12 (04min)

› The molecular basis for zinc uptake via Streptococcus pneumoniae AdcAII - 15:12-15:16 (04min)

› The role of Clostridium difficile's flavodiiron proteins in its ability to survive within the human host - 15:16-15:20 (04min)

Metals in health and diseases

15:45 - 17:10 (1h25)

Metals in health and diseases

Main room

Liz Nolan

› New role of copper protein in cancer - 15:47-16:17 (30min)

› Metal-induced aggregation of gamma-crystallins: Insights into the bioinorganic chemistry of cataract disease - 16:19-16:49 (30min)

› Metal ion dyshomeostasis and coagulatory defects in type-1 and type-2 diabetes - 16:51-17:07 (16min)

Discussion Rooms

17:10 - 17:30 (20min)

Discussion Rooms

Metals in health and diseases

17:30 - 18:00 (30min)

Metals in health and diseases

Liz Nolan

› Intestinal copper regulates fat absorption - 17:30-18:00 (30min)

Metals and drugs

18:00 - 19:25 (1h25)

Metals and drugs

Katharina Frömm

› New inhibitors against the [4Fe-4S] quinolinate synthase - 18:02-18:18 (16min)

› Modifiable metal affinity chromatography as a metalloenzyme surrogate - 18:19-18:35 (16min)

› Vanadium compounds activate cell signaling: the importance of speciation - 18:36-18:52 (16min)

› Imaging metal complexes in cells - Clotilde Policar (invited) 18:53-19:23 (30min)

Discussion Rooms

19:25 - 19:45 (20min)

Discussion Rooms

Metalloproteins and biogenesis

15:00 - 16:40 (1h40)

Metalloproteins and biogenesis

Main room

Aixin Yan

› Nickel trafficking in the urease system - 15:00-15:30 (30min)

› Lactate Racemase and its Novel Nickel-Pincer Nucleotide Cofactor - 15:32-16:02 (30min)

› A structural view of the nickel delivery pathway in urease maturation - 16:04-16:20 (16min)

› Escherichia coli Repair of Iron Centres YtfE Protein Interacts with the DNA-Binding Protein from Starved cells Dps Protein - 16:21-16:37 (16min)

Metalloproteins and biogenesis
Metals and drugs

16:40 - 17:10 (30min)

Metalloproteins and biogenesis

Main room

Flash - Robert Hausinger

› The role of a quasi-conserved domain in flavodiiron NO reductases - 16:40-16:44 (04min)

› The multidomain flavodiiron protein from Syntrophomonas wolfei - 16:44-16:48 (04min)

› Synthesis of biohybrid electrode materials for hydrogen evolution - 16:48-16:52 (04min)

› Putative phosphorylation of Escherichia coli anaerobic nitric oxide reductase flavorubredoxin - 16:52-16:56 (04min)

› Insights into determinants of the activity of the flavodiiron NO reductase from E. coli - 16:56-17:00 (04min)

16:40 - 17:10 (30min)

Metals and drugs

Auxiliary Room

Flash - Liliana Quintanar

› Preclinical Anticancer Evaluation of an Electron-Deficient Organoruthenium(II) Complex - Maria Azmanova, University of Bradford 16:40-16:44 (04min)

› Appended aromatic moieties determine the Cytotoxicity of Neutral Cyclometalated Platinum(II) complexes derived from 2-(2-Pyridyl)benzimidazole - 16:44-16:48 (04min)

› Anticancer Activity of Neutral Cyclometalated Platinum(II) complexes bearing imidazole derivatives - 16:48-16:52 (04min)

› Photoactivation of Dual Antibacterial and Anticancer Activities of New Luminescent 2-Benzoazole-Phenolato Cycloplatinated(II) Complexes. - 16:52-16:56 (04min)

› Reversible BSA aggregation by Cu2-complexes with metalloproteins active sites as potential antitumoral drug delivery process: a scattering study - 16:56-17:00 (04min)

Discussion Rooms

17:10 - 17:30 (20min)

Discussion Rooms

Visualization and quantification of metals

17:30 - 18:50 (1h20)

Visualization and quantification of metals

Main room

Clotilde Policar

› Elemental bioimaging and speciation analysis to track gadolinium retention from MRI contrast agents in the body - 17:30-18:00 (30min)

› Maternal-developmental undernourishment alters copper homeostasis in the rat kidney and liver - 18:02-18:18 (16min)

› Metals and morphological synaptic plasticity: insights from correlative super resolution and synchrotron imaging - 18:19-18:49 (30min)

Discussion Rooms

18:50 - 19:05 (15min)

Discussion Rooms

Closing and awards

19:05 - 19:20 (15min)

Closing and awards

Chairman and IBS