Monday, July 6, 2020

Time Event  
15:00 - 15:10 Welcome and Introduction - Chairman and IBS  
15:10 - 16:00 Plenary Speech (Main room) - Hans Vogel  
15:10 - 16:00 › Metal Sequestration by Calprotectin and Consequences on Microbial Physiology - Elizabeth Nolan, Massachusetts Institute of Technology  
16:00 - 16:50 BioMetals (Main room) - David Giedroc  
16:02 - 16:32 › How cells help proteins to acquire the correct metals: Free energies of metalation - Nigel J. Robinson - Department of Biosciences and Department Chemistry [Durham University]  
16:34 - 16:50 › Specificity factors that govern zinc-dependent assembly of CD4 coreceptor and Lck tyrosine kinase - Anna Kocyla - Department of Chemical Biology, Faculty of Biotechnology, University of Wroclaw  
16:50 - 17:20 Metals and host-pathogen interactions (Main room) - Flash - Simon Andrews  
16:50 - 16:54 › The events that may contribute to subgingival dysbiosis: a focus on the interplay between iron, sulfide and oxygen - Christine Baysse - University Rennes 1 NUMECAN U1241 CIMIAD  
16:54 - 16:58 › Identification and characterization of iron transporters in Enterococcus faecalis - Debra Brunson - University of Florida  
16:58 - 17:02 › Effect of iron on the development of oral biofilm. - Kanchana Chathoth - NUMECAN U1241 INSERM CIMIAD, Faculté d'Odontologie  
17:02 - 17:06 › The influence of iron regime on the human gut microflora – an in vitro batch culture approach - Amro Duhduh - School of Biological Sciences [Reading]  
17:06 - 17:10 › The role of the three lipocalins of egg-white in inhibition of Salmonella Enteritidis under iron restriction - Louis Julien - Institut Agro, School of Biological Sciences [Reading]  
16:50 - 17:20 Metalloproteins and biogenesis (Auxiliary Room) - Flash - Stefano Ciurli  
16:50 - 16:54 › A luminescent peptide probe for extracellular Cu(II) detection - Enrico FALCONE - Institut de Chimie de Strasbourg  
16:54 - 16:58 › OXIDATIVE STRESS RESPONSE ENZYMES: UNRAVELLING CATALYTIC DETERMINANTS OF SUPEROXIDE REDUCTASES THROUGH NATURAL AND SITE DIRECTED MUTANTS - Diniz Diogo - Instituto de Tecnologia Quimica e Biologica  
16:58 - 17:02 › Copper (I) oxidation by a CueO-like oxidase from T. thermophilus studied by direct electrochemistry - Ievgen Mazurenko - Bioénergétique et Ingénierie des Protéines (BIP)  
17:02 - 17:06 › Biogenesis of Iron-Sulphur cluster binding proteins in human cytosol: An insight into the molecular mechanism of cluster delivery from GLRX3 to NUBP1 - Nihar Ranjan Prusty - Magnetic Resonance Center CERM, University of Florence  
17:06 - 17:10 › Biochemical and structural characterization of a new Flavorubredoxin from Photobacterium swingsii - Bruno Salgueiro - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa  
17:20 - 17:40 Discussion Rooms  
17:40 - 19:35 Metals and host-pathogen interactions (Main room) - John Helmann  
17:40 - 18:10 › Sensing the environment and the host: Iron transport and signalling in Pseudomonas - Maria Llamas - Department of Environmental Protection  
18:12 - 18:28 › Necrotrophic phytopathogens are protected from reactive oxygen species by a secreted metal-binding protein - Agnès Rodrigue - Microbiolohie, adaptation et pathogénie  
18:29 - 18:45 › Effect of Iron on the Composition and Activity of the Gut Microbiota using in vitro Models - Andrea Monteagudo-Mera - School of Biological Sciences [Reading]  
18:46 - 19:02 › Haem biosynthesis in Campylobacter jejuni - Jordi Zamarreño Beas - Instituto de Tecnologia Química é Biológica, Universidade Nova de Lisboa  
19:03 - 19:33 › Metallobiology at the host-pathogen interface: the case of tuberculosis - Olivier Neyrolles (invited)  
19:35 - 19:45 Discussion Rooms  

Tuesday, July 7, 2020

Time Event  
15:00 - 16:40 Metal trafficking in micro-organisms (Main room) - Nigel Robinson  
15:00 - 15:30 › Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli - Aixin Yan - School of Biological Sciences, The University of Hong Kong  
15:32 - 16:02 › The three pillars of bacterial zinc homeostasis - Dietrich Nies - Martin-Luther-University Halle-Wittenberg  
16:04 - 16:20 › The Bacillus anthracis virulence-determinant ABC transporter MntBC-A: transport specificity and trans-membrane metal recognition - Oded Lewinson - Department of Molecular Microbiology, Faculty of Medicine  
16:21 - 16:37 › Characterization of the Vibrio cholerae Feo Iron Transport System - Shelley Payne - University of Texas at Austin [Austin]  
16:40 - 17:10 Metal trafficking in micro-organisms (Main room) - Flash - Dietrich Nies  
16:40 - 16:44 › Investigating components of a Campylobacter jejuni gene cluster upregulated for iron scavenging during human infection - Tomas Richardson-Sanchez - Department of Microbiology & Immunology, University of British Columbia  
16:44 - 16:48 › The importance of conserved residues and the C-terminal sub-domain in FeoB-mediated iron uptake - SALEM AL-AIDY - School of Biological Sciences [Reading], University of Wasit/College of Medicine  
16:48 - 16:52 › The Cup determinant is crucial for the resistance to copper in Cupriavidus metallidurans - Niklas Hirth - Martin Luther Universität Halle, Institute for Molecular Microbiology  
16:52 - 16:56 › Siroheme biosynthesis in Staphylococcus aureus: insights of the pathway evolution in bacteria - Marco Videira - ITQB-NOVA  
16:40 - 17:10 Metals in health and diseases (Auxiliary Room) - Flash - Isabelle Michaud-Soret  
16:40 - 16:44 › Empirical evidence supports an aetiological role for changes in biometal pathways in Parkinson's disease - Amr Abdeen - Brain and Mind Centre and Discipline of Pharmacology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney  
16:44 - 16:48 › Long-lived kinetic intermediates explain Cu(II) exchange processes in ATCUN peptides - Radosław Kotuniak - Institute of Biochemistry and Biophysics Polish Academy of Sciences  
16:48 - 16:52 › B. cenocepacia increased antimicrobial resistance in the Cystic Fibrosis lung is associated with low pH and elevated levels of zinc and iron - Laura Daniela Morales - Department of Microbiology and Immunology,University of British Columbia  
16:52 - 16:56 › Design and study of anti-oxidant inorganic complexes mimicking the superoxide dismutase (SOD) - Gabrielle Schanne - Laboratoire des biomolécules  
16:56 - 17:00 › Discovery through combinatorial chemistry of a peptidyl metal complex mimicking the antioxidant enzyme Catalase: characterization and in vitro/in vivo activity - Koudedja Couliably, Laboratoire des biomolécules  
17:10 - 17:30 Discussion Rooms  
17:30 - 18:00 Metal trafficking in micro-organisms (Main room) - Dietrich Nies  
17:30 - 18:00 › How bacteria cope with silver ions - Katharina Fromm - Université de Fribourg, Department of Chemistry, University of Fribourg  
18:00 - 19:25 Siderophores, metallophores and chelators (Main room) - Debbie Crans  
18:02 - 18:32 › The ancient roots of nicotianamine:diversity, role, regulation and evolution of nicotanamine-like metallophores - Pascal Arnoux - CEA Cadarache  
18:34 - 18:50 › Simple rules govern the diversity of bacterial nicotianamine-like metallophores - Clémentine Laffont - Aix-Marseille University, Pascal Arnoux - CEA - BIAM  
18:51 - 19:07 › Phenotypic adaptation of Pseudomonas aeruginosa in the presence of exosiderophores. - Quentin Perraud  
19:08 - 19:24 › Iron acquisition by Streptococcus pneumoniae: PiuA specifically recognizes tetradentate catechol FeIII complexes - Katherine A. Edmonds - Indiana University [Bloomington]  
19:25 - 19:45 Discussion Rooms  

Wednesday, July 8, 2020

Time Event  
15:00 - 15:30 Siderophores, metallophores and chelators (Auxiliary Room) - Flash - Pascal Arnoux  
15:00 - 15:04 › Azido-Desferrioxamine Siderophores as Functional Click- Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent - Michael Gotsbacher - University of Sydney  
15:04 - 15:08 › Elucidating the mechanism for the biosynthesis of N-acetyl desferrioxamine siderophores - Kate Nolan - School of Medical Sciences (Pharmacology), The University of Sydney, Australia  
15:08 - 15:12 › A Novel Total Synthetic Approach to Desferrioxamine B Analogues - Athavan Sresutharsan - School of Medical Sciences (Pharmacology), The University of Sydney, Australia  
15:12 - 15:16 › IRON (III) AND GALLIUM (III) COMPLEXES OF FERRIOXAMINE E BIOMIMETIC ANALOGS - COORDINATION SPECIFICITY AND POSSIBLE APPLICATIONS - Andrzej Mular - Faculty of Chemistry, University of Wroclaw  
15:00 - 15:30 Metals and environment (Main room) - Flash - Katharina Frömm  
15:00 - 15:04 › Deinococcus radiodurans' protection mechanisms against oxidative stress triggers the delocalization of intracellular metals - Célia Romão - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)  
15:04 - 15:08 › Discovery and characterization of UipA, a uranium-binding protein involved in bacterial uranium tolerance - Abbas Mohamad Ali - Institut de Biosciences et Biotechnologies dÁix-Marseille (ex-IBEB)  
15:08 - 15:12 › In vitro biological water-gas shift reaction: characterization and grafting of recombinant Rhodospirillum rubrum CO-dehydrogenase - Umberto CONTALDO - Laboratoire de Chimie et Biologie des Métaux  
15:12 - 15:16 › Molecular mechanisms of Resistance to Radiation - Sara Silva - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)  
15:16 - 15:20 › Dissecting the mechanism of cadmium toxicity in Deinococcus radiodurans R1 - Ruchi Chaturvedi - Department of Biological Sciences.  
15:30 - 16:55 Metals and environment (Main room) - Richard Ortega  
15:32 - 16:02 › The fate of uranium in plants – Physiological and cellular effects - Jacques Bourguignon - Université Grenoble Alpes  
16:04 - 16:20 › Elucidating the mechanism of uranium uptake and processing in tobacco BY-2 cells - Warren John - Helmholtz-Zentrum Dresden-Rossendorf  
16:21 - 16:37 › A highly sensitive magnetic whole-cell biosensor for arsenic detection - Anissa Dieudonné - BIAM, CEA Cadarache  
16:38 - 16:54 › In vivo speciation and uptake mechanisms of Uranium in Paracentrotus lividus sea urchin and Laminaria digitata seaweed - Maria Rosa BECCIA - Institut de Chimie de Nice  
16:55 - 17:05 Group picture - on screens  
17:05 - 17:20 Discussion Rooms  
17:20 - 19:30 Metal homeostasis and regulation (Main room) - Claudia Blindauer  
17:20 - 17:50 › Manganese homeostasis in Bacillus subtilis - John D. Helmann - Department of Microbiology [Cornell University]  
17:52 - 18:22 › Metalloregulation of cyanobacterial physiology operated by FUR (ferric uptake regulator) proteins - María F. Fillat - Departamento de Bioquímica y Biología Molecular y Celular and Instituto de Biocomputación y Física de Sistemas Complejos [Zaragoza]  
18:24 - 18:40 › Characterization of the stress-induced molecular signal that activates IrrE, a metalloprotease essential for extreme radiation resistance in Deinococcus bacteria. - Nicolaas Arjan DE GROOT - CEA-DRF-BIAM-MEM  
18:41 - 18:57 › Zinc and iron homeostasis adjust a core metalloproteome and is reflected by the cellular metal composition, the metallome. - Martin Herzberg  
18:58 - 19:28 › A single zinc sensor mediates the response of an oligotrophic marine cyanobacterium to zinc excess and starvation - Claudia Blindauer (invited)  
19:30 - 19:55 Discussion Rooms  

Thursday, July 9, 2020

Time Event  
15:00 - 15:45 Metal homeostasis and regulation (Main room) - Flash + oral - John Helmann  
15:00 - 15:04 › Copper stress induces protein aggregation and triggers Hsp33 holdase function through a non-redox mechanism. - Marianne Ilbert - Bioénergétique et Ingénierie des Protéines  
15:04 - 15:08 › Structural properties of the transcriptional regulator FurC (PerR) from Anabaena sp. PCC7120 and identification of a putative FurC-box - Cristina Sarasa - Department of Biochemistry and Molecular and Cell Biology and Institute for Biocomputation and Physics of Complex Systems, Faculty of sciences [Zaragoza]  
15:08 - 15:12 › Structural characterization of Deinococcus radiodurans Dps2 with manganese: Expression, purification and crystallization - André Gouveia - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA)  
15:12 - 15:16 › Interaction of Ferric Uptake Regulator FurA from Anabaena sp. PCC7120 with 2-oxoglutarate: a possible link between iron homeostasis and nitrogen metabolism - Jorge Guío - Department of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Institute for Biocomputation and Physics of Complex Systems  
15:16 - 15:20 › Characterization of the stress-induced molecular signal that activates IrrE, a metalloprotease essential for extreme radiation resistance in Deinococcus bacteria. - Romaric Magerand, CEA-DRF-BIAM-MEM  
15:30 - 15:46 › Structural and Functional Characterization of Heme-Regulated Proteins in Iron Metabolism - Koichiro Ishimori - Hokkaido University  
15:00 - 15:30 Metals and host-pathogen interactions (Auxiliary Room) - Flash - Alain Stintzi  
15:00 - 15:04 › Overcoming metal intoxication – Elucidating the zinc resistance pathways of Acinetobacter baumannii - Saleh Alquethamy - Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne  
15:04 - 15:08 › Biochemical and structural characterisation of the Haemophilus influenzae PsaA ortholog, HIPsaA - Katherine Ganio - The Peter Doherty Institute for Infection and Immunity  
15:08 - 15:12 › Metal Sequestration and Antimicrobial Activity of Human Calprotectin are pH-Dependent - Tomer Rosen - Department of Chemistry, Massachusetts Institute of Technology  
15:12 - 15:16 › The molecular basis for zinc uptake via Streptococcus pneumoniae AdcAII - Marina Zupan - Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia  
15:16 - 15:20 › The role of Clostridium difficile's flavodiiron proteins in its ability to survive within the human host - Filipe Folgosa - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal  
15:45 - 17:10 Metals in health and diseases (Main room) - Liz Nolan  
15:47 - 16:17 › New role of copper protein in cancer - Stephanie Blockhuys - Chalmers University of Technology  
16:19 - 16:49 › Metal-induced aggregation of gamma-crystallins: Insights into the bioinorganic chemistry of cataract disease - Liliana Quintanar - Department of Chemistry, Center for Research and Advanced Studies (Cinvestav)  
16:51 - 17:07 › Metal ion dyshomeostasis and coagulatory defects in type-1 and type-2 diabetes - Alan J. Stewart - University of St Andrews  
17:10 - 17:30 Discussion Rooms  
17:30 - 18:00 Metals in health and diseases - Liz Nolan  
17:30 - 18:00 › Intestinal copper regulates fat absorption - Svetlana Lutsenko - Department of Physiology, Johns Hopkins University  
18:00 - 19:25 Metals and drugs - Katharina Frömm  
18:02 - 18:18 › New inhibitors against the [4Fe-4S] quinolinate synthase - Sandrine Ollagnier - Laboratoire de Chimie et Biologie des Métaux  
18:19 - 18:35 › Modifiable metal affinity chromatography as a metalloenzyme surrogate - Lukas Roth - University of Sydney  
18:36 - 18:52 › Vanadium compounds activate cell signaling: the importance of speciation - debbie crans - Colorado State University, Department of Chemistry, Colorado State University  
18:53 - 19:23 › Imaging metal complexes in cells - Clotilde Policar (invited)  
19:25 - 19:45 Discussion Rooms  

Friday, July 10, 2020

Time Event  
15:00 - 16:40 Metalloproteins and biogenesis (Main room) - Aixin Yan  
15:00 - 15:30 › Nickel trafficking in the urease system - Stefano Ciurli - Laboratory of Bio-Inorganic Chemistry [Bologna]  
15:32 - 16:02 › Lactate Racemase and its Novel Nickel-Pincer Nucleotide Cofactor - Robert P. Hausinger - Departments of Microbiology & Molecular Genetics and Biochemistry & Molecular Biology [Michigan]  
16:04 - 16:20 › A structural view of the nickel delivery pathway in urease maturation - Kam Bo Wong - School of Life Sciences, The Chinese University of Hong Kong  
16:21 - 16:37 › Escherichia coli Repair of Iron Centres YtfE Protein Interacts with the DNA-Binding Protein from Starved cells Dps Protein - Liliana Silva - ITQB-NOVA  
16:40 - 17:10 Metalloproteins and biogenesis (Main room) - Flash - Robert Hausinger  
16:40 - 16:44 › The role of a quasi-conserved domain in flavodiiron NO reductases - Susana Fernandes - ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier  
16:44 - 16:48 › The multidomain flavodiiron protein from Syntrophomonas wolfei - Maria C. Martins - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal  
16:48 - 16:52 › Synthesis of biohybrid electrode materials for hydrogen evolution - Afridi Zamader - Laboratoire de Chimie et Biologie des Métaux  
16:52 - 16:56 › Putative phosphorylation of Escherichia coli anaerobic nitric oxide reductase flavorubredoxin - Silviya R Stateva - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa  
16:56 - 17:00 › Insights into determinants of the activity of the flavodiiron NO reductase from E. coli - Jéssica Soares - Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal  
16:40 - 17:10 Metals and drugs (Auxiliary Room) - Flash - Liliana Quintanar  
16:40 - 16:44 › Preclinical Anticancer Evaluation of an Electron-Deficient Organoruthenium(II) Complex - Maria Azmanova, University of Bradford  
16:44 - 16:48 › Appended aromatic moieties determine the Cytotoxicity of Neutral Cyclometalated Platinum(II) complexes derived from 2-(2-Pyridyl)benzimidazole - MONICA VAQUERO - Facultad de Ciencias, Universidad de Burgos  
16:48 - 16:52 › Anticancer Activity of Neutral Cyclometalated Platinum(II) complexes bearing imidazole derivatives - Natalia Fernández - (Universidad de Burgos)  
16:52 - 16:56 › Photoactivation of Dual Antibacterial and Anticancer Activities of New Luminescent 2-Benzoazole-Phenolato Cycloplatinated(II) Complexes. - Natalia Busto - Departamento de Química, Universidad de Burgos  
16:56 - 17:00 › Reversible BSA aggregation by Cu2-complexes with metalloproteins active sites as potential antitumoral drug delivery process: a scattering study - Jesica Paola Rada - Pontifícia Universidade Católica do Rio de Janeiro  
17:10 - 17:30 Discussion Rooms  
17:30 - 18:50 Visualization and quantification of metals (Main room) - Clotilde Policar  
17:30 - 18:00 › Elemental bioimaging and speciation analysis to track gadolinium retention from MRI contrast agents in the body - Michael Sperling - University of Münster, Institute of Inorganic and Analytical Chemistry  
18:02 - 18:18 › Maternal-developmental undernourishment alters copper homeostasis in the rat kidney and liver - Alma Isabel Santos-Díaz - CINVESTAV  
18:19 - 18:49 › Metals and morphological synaptic plasticity: insights from correlative super resolution and synchrotron imaging - Richard Ortega - Chemical Imaging and Speciation [Bordeaux]  
18:50 - 19:05 Discussion Rooms  
19:05 - 19:20 Closing and awards - Chairman and IBS  

Saturday, July 11, 2020

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Sunday, July 12, 2020

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Monday, July 13, 2020

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Tuesday, July 14, 2020

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Wednesday, July 15, 2020

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Thursday, July 16, 2020

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Friday, July 17, 2020

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Saturday, July 18, 2020

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